MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

ABSTRACT The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition that restricts viral infectivity. However, how HIV-1 counters this restriction, notably during infection of macro...

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Bibliographic Details
Main Authors: Robert Lodge, Zaikun Xu, Mckenna Eklund, Christina Stürzel, Frank Kirchhoff, Michel J. Tremblay, Tom C. Hobman, Éric A. Cohen
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
human immunodeficiency virus
microRNA
restriction factor
viral glycoproteins
MARCH proteins
HIV-1 countermeasures
Online Access:https://journals.asm.org/doi/10.1128/mbio.01950-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01950-23

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