CD44 Glycosylation as a Therapeutic Target in Oncology

CD44 Glycosylation as a Therapeutic Target in Oncology

The interaction of non-kinase transmembrane glycoprotein CD44 with ligands including hyaluronic acid (HA) is closely related to the occurrence and development of tumors. Changes in CD44 glycosylation can regulate its binding to HA, Siglec-15, fibronectin, TM4SF5, PRG4, FGF2, collagen and podoplanin...

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Bibliographic Details
Main Authors: Chengcheng Liao, Qian Wang, Jiaxing An, Jie Chen, Xiaolan Li, Qian Long, Linlin Xiao, Xiaoyan Guan, Jianguo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
CD44
glycosylation
hyaluronic acid
fucosylation
sialylation
HCELL
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.883831/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.883831/full

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