Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

Abstract Approximately 20 TP53 retrogenes exist in the African and Asian elephant genomes (Loxodonta Africana, Elephas Maximus) in addition to a conserved TP53 gene that encodes a full-length protein. Elephant TP53-RETROGENE 9 (TP53-R9) encodes a p53 protein (p53-R9) that is truncated in the middle...

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Bibliographic Details
Main Authors: Aidan J. Preston, Aaron Rogers, Miranda Sharp, Gareth Mitchell, Cristhian Toruno, Brayden B. Barney, Lauren N. Donovan, Journey Bly, Ryan Kennington, Emily Payne, Anthony Iovino, Gabriela Furukawa, Rosann Robinson, Bahar Shamloo, Matthew Buccilli, Rachel Anders, Sarah Eckstein, Elizabeth A. Fedak, Tanner Wright, Carlo C. Maley, Wendy K. Kiso, Dennis Schmitt, David Malkin, Joshua D. Schiffman, Lisa M. Abegglen
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01348-7

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https://doi.org/10.1038/s41420-023-01348-7

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