Persistent and Severe Viral Replication in PBMCs with Moderate Immunosuppression Served an Alternative Novel Pathogenic Mechanism for Canine Morbillivirus

Persistent and Severe Viral Replication in PBMCs with Moderate Immunosuppression Served an Alternative Novel Pathogenic Mechanism for Canine Morbillivirus

ABSTRACT Measles virus and canine distemper virus (CDV) cause lethal infections in their respective hosts characterized by severe immunosuppression. To furtherly acknowledge the attenuated mechanisms of the regionally ongoing epidemic CDV isolates and provide novel perspectives for designing new vac...

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Bibliographic Details
Main Authors: Chuchu Feng, Yan Bu, Jiaxi Cai, Guanyu Zhao, Zishu Li, Yuening Cheng, Xiaohao Zhang, Yijun Shi, Yang Gao, Xiangnan Li, Xuexing Zheng, Xianghong Xue
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
canine distemper virus
immunosuppression
pathogenic mechanisms
viremia
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04060-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04060-22

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