Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels

AbstractA series of 1H-benzo[f]chromene moieties (4a–z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules has been explored against three cancer cells: M...

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Bibliographic Details
Main Authors: Laila M. Al-Harbi, Eman A. Al-Harbi, Rawda M. Okasha, R. A. El-Eisawy, Mohammed A. A. El-Nassag, Hany M. Mohamed, Ahmed M. Fouda, Ahmed A. Elhenawy, Ahmed Mora, Ahmed M. El-Agrody, Heba K. A. El-Mawgoud
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Ultrasound synthesis
1H-Benzo[f]chromenes
antitumor activity
MCF-7/ADR
P-glycoprotein
western blot
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2155814

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https://www.tandfonline.com/doi/10.1080/14756366.2022.2155814

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