Effects of substrate modifications on the arginine dimethylation activities of PRMT1 and PRMT5

Effects of substrate modifications on the arginine dimethylation activities of PRMT1 and PRMT5

Histone arginine methylation is a prevalent posttranslational modification (PTM) in eukaryotic cells and contributes to the histone codes for epigenetic regulation of gene transcription. In this study, we determined how local changes on adjacent residues in the histone H4 substrate regulate arginine...

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Bibliographic Details
Main Authors: Melody D. Fulton, Tran Dang, Tyler Brown, Y. George Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Epigenetics
Subjects:
prmt
arginine methylation
adma
sdma
acetylation
phosphorylation
histone
posttranslational modification
epigenetics
Online Access:http://dx.doi.org/10.1080/15592294.2020.1864170

Internet

http://dx.doi.org/10.1080/15592294.2020.1864170

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