Three-dimensional nuclear telomere architecture and differential expression of aurora kinase genes in chronic myeloid leukemia to measure cell transformation

Three-dimensional nuclear telomere architecture and differential expression of aurora kinase genes in chronic myeloid leukemia to measure cell transformation

Abstract Background Telomere dysfunction results in aneuploidy, and ongoing chromosomal abnormalities. The three-dimensional (3D) nuclear organization of telomeres allows for a distinction between normal and tumor cells. On the other hand, aurora kinase genes (AURKA and AURKB) play an important role...

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Bibliographic Details
Main Authors: Fábio Morato de Oliveira, Valderez Ravaglio Jamur, Lismeri Wuicik Merfort, Aline Rangel Pozzo, Sabine Mai
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Cancer
Subjects:
CML
Telomere
Nuclear architecture
Genomic instability
Online Access:https://doi.org/10.1186/s12885-022-10094-5

Internet

https://doi.org/10.1186/s12885-022-10094-5

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