SK4 channels modulate Ca2+ signalling and cell cycle progression in murine breast cancer

SK4 channels modulate Ca2+ signalling and cell cycle progression in murine breast cancer

Oncogenic signalling via Ca2+‐activated K+ channels of intermediate conductance (SK4, also known as KCa3.1 or IK) has been implicated in different cancer entities including breast cancer. Yet, the role of endogenous SK4 channels for tumorigenesis is unclear. Herein, we generated SK4‐negative tumours...

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Bibliographic Details
Main Authors: Friederike A. Steudel, Corinna J. Mohr, Benjamin Stegen, Hoang Y. Nguyen, Andrea Barnert, Marc Steinle, Sandra Beer‐Hammer, Pierre Koch, Wing‐Yee Lo, Werner Schroth, Reiner Hoppe, Hiltrud Brauch, Peter Ruth, Stephan M. Huber, Robert Lukowski
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:Molecular Oncology
Subjects:
breast cancer
Ca2+‐activated K+ channels of intermediate conductance (SK4, KCa3.1, IK, KCNN4)
epidermal growth factor receptor 2 (Her2/cNeu)
mouse mammary tumour virus (MMTV)
polyoma virus middle T‐antigen (PyMT)
Online Access:https://doi.org/10.1002/1878-0261.12087

Internet

https://doi.org/10.1002/1878-0261.12087

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