Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation

Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation

Olfactory and rapid eye movement (REM) sleep deficits are commonly found in untreated subjects with a recent diagnosis of Parkinson's disease (PD). Besides different studies reported declines in olfactory performances during a short period of sleep deprivation. Mechanisms underlying these clini...

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Bibliographic Details
Main Authors: Laís Soares Rodrigues, Adriano eTarga, Ana Carolina Duarte Noseda, Mariana F Aurich, Cláudio eDa Cunha, Marcelo M. S. Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dopamine
Olfactory Bulb
REM sleep deprivation
olfactory discrimination
bulbar dopaminergic D2 receptors
intranigral
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00383/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00383/full

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