Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

A novel plant sesquiterpene lactone derivative, DET derivative (DETD)-35, originating from parental deoxyelephantopin (DET) was previously observed to effectively suppress human triple negative breast cancer (TNBC) MDA-MB-231 cell activity and tumor growth in mice. In this study, the mechanisms unde...

Full description

Bibliographic Details
Main Authors: Jeng-Yuan Shiau, Yong-Qun Chang, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
sesquiterpene lactone
oxidative stress
exosomal proteome
cancer therapy
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00398/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00398/full

Similar Items