Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F420 and Its Derivative 3PG-F420

Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F420 and Its Derivative 3PG-F420

ABSTRACT Coenzyme F420 is a microbial redox cofactor that mediates diverse physiological functions and is increasingly used for biocatalytic applications. Recently, diversified biosynthetic routes to F420 and the discovery of a derivative, 3PG-F420, were reported. 3PG-F420 is formed via activation o...

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Bibliographic Details
Main Authors: Mahmudul Hasan, Sabrina Schulze, Leona Berndt, Gottfried J. Palm, Daniel Braga, Ingrid Richter, Daniel Last, Michael Lammers, Gerald Lackner
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
bacterial metabolism
biosynthesis
coenzyme
enzyme catalysis
substrate specificity
X-ray crystallography
Online Access:https://journals.asm.org/doi/10.1128/mbio.03501-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03501-21

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