Array comparative genomic hybridization identifies high level of PI3K/Akt/mTOR pathway alterations in anal cancer recurrences

Array comparative genomic hybridization identifies high level of PI3K/Akt/mTOR pathway alterations in anal cancer recurrences

Abstract Genomic alterations of anal squamous cell carcinoma (ASCC) remain poorly understood due to the rarity of this tumor. Array comparative genomic hybridization and targeted gene sequencing were performed in 49 cases of ASCC. The most frequently altered regions (with a frequency greater than 25...

詳細記述

書誌詳細
主要な著者: Wulfran Cacheux, Petros Tsantoulis, Adrien Briaux, Sophie Vacher, Pascale Mariani, Marion Richard‐Molard, Bruno Buecher, Sophie Richon, Emmanuelle Jeannot, Julien Lazartigues, Etienne Rouleau, Odette Mariani, Elsy El Alam, Jérôme Cros, Sergio Roman‐Roman, Emmanuel Mitry, Elodie Girard, Virginie Dangles‐Marie, Astrid Lièvre, Ivan Bièche
フォーマット: 論文
言語:English
出版事項: Wiley 2018-07-01
シリーズ:Cancer Medicine
主題:
anal squamous cell carcinoma
array comparative genomic hybridization
copy number alterations
PI3K/Akt/mTOR signaling pathway
somatic mutations
オンライン･アクセス:https://doi.org/10.1002/cam4.1533

インターネット

https://doi.org/10.1002/cam4.1533

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