Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways

Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways

Benign prostatic hyperplasia (BPH) is a common urinary disease among the elderly, characterized by abnormal prostatic cell proliferation. Neferine is a dibenzyl isoquinoline alkaloid extracted from Nelumbo nucifera and has antioxidant, anti-inflammatory and anti-prostate cancer effects. The benefici...

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Bibliographic Details
Main Authors: Chi-Ming Liu, ZiChen Shao, XuZhou Chen, HanWu Chen, MengQiao Su, ZiWen Zhang, ZhengPing Wu, Peng Zhang, LiJie An, YinJie Jiang, Ai-Jun Ouyang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Saudi Pharmaceutical Journal
Subjects:
Benign prostatic hyperplasia (BPH)
Androgen receptor (AR)
TGF-β/Smad
Neferine
Epithelial-mesenchymal transition (EMT)
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423001238

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http://www.sciencedirect.com/science/article/pii/S1319016423001238

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