Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles

Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles

Several COVID-19 vaccine strategies utilizing new formulations for the induction of neutralizing antibodies (nAbs) and T cell immunity are still under evaluation in preclinical and clinical studies. Here we used Simian Immunodeficiency Virus (SIV)-based integrase defective lentiviral vector (IDLV) d...

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Bibliographic Details
Main Authors: Martina Borghi, Alessandra Gallinaro, Maria Franca Pirillo, Andrea Canitano, Zuleika Michelini, Maria Laura De Angelis, Serena Cecchetti, Antonella Tinari, Chiara Falce, Sabrina Mariotti, Antonio Capocefalo, Maria Vincenza Chiantore, Angelo Iacobino, Antonio Di Virgilio, Marit J. van Gils, Rogier W. Sanders, Alessandra Lo Presti, Roberto Nisini, Donatella Negri, Andrea Cara
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
lentiviral vector (LV)
IDLV
vaccine
SARS-CoV-2
neutralizing Abs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147953/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147953/full

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