Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.

Bibliographic Details
Main Authors: Quanbo Ji, Xiaojie Xu, Lei Kang, Yameng Xu, Jingbo Xiao, Stuart B. Goodman, Xiang Zhu, Wenchao Li, Juan Liu, Xu Gao, Zhifeng Yan, Yuxuan Zheng, Zheng Wang, William J. Maloney, Qinong Ye, Yan Wang
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08277-5

Internet

https://doi.org/10.1038/s41467-018-08277-5

Similar Items