Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches

Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches

ABSTRACT The ability to sense and respond to intracellular metabolite levels enables cells to adapt to environmental conditions. Many prokaryotes use riboswitches—structured RNA elements usually located in the 5′ untranslated region of mRNAs—to sense intracellular metabolites and respond by modulati...

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Bibliographic Details
Main Authors: Rebecca R. Procknow, Kristopher J. Kennedy, Maxwell Kluba, Lesley J. Rodriguez, Michiko E. Taga
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
riboswitch
corrinoid
cobalamin
gene regulation
Bacillus subtilis
RNA biology
Online Access:https://journals.asm.org/doi/10.1128/mbio.01588-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01588-23

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