High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.

Pore-forming proteins (PFPs) represent a functionally important protein family, that are found in organisms from viruses to humans. As a major branch of PFPs, bacteria pore-forming toxins (PFTs) permeabilize membranes and usually cause the death of target cells. E. coli hemolysin ClyA is the first m...

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Bibliographic Details
Main Authors: Wei Peng, Marcela de Souza Santos, Yang Li, Diana R Tomchick, Kim Orth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213423