Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption

Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption

Summary: Pneumolysin (Ply) is an indispensable cholesterol-dependent cytolysin for pneumococcal infection. Although Ply-induced disruption of pneumococci-containing endosomal vesicles is a prerequisite for the evasion of endolysosomal bacterial clearance, its potent activity can be a double-edged sw...

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Bibliographic Details
Main Authors: Sayaka Shizukuishi, Michinaga Ogawa, Eisuke Kuroda, Shigeto Hamaguchi, Chisato Sakuma, Soichiro Kakuta, Isei Tanida, Yasuo Uchiyama, Yukihiro Akeda, Akihide Ryo, Makoto Ohnishi
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002900

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http://www.sciencedirect.com/science/article/pii/S2211124724002900

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