Isolation of Human Colon Stem Cells Using Surface Expression of PTK7

Isolation of Human Colon Stem Cells Using Surface Expression of PTK7

Insertion of reporter cassettes into the Lgr5 locus has enabled the characterization of mouse intestinal stem cells (ISCs). However, low cell surface abundance of LGR5 protein and lack of high-affinity anti-LGR5 antibodies represent a roadblock to efficiently isolate human colonic stem cells (hCoSCs...

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Bibliographic Details
Main Authors: Peter Jung, Christian Sommer, Francisco M. Barriga, Simon J. Buczacki, Xavier Hernando-Momblona, Marta Sevillano, Miquel Duran-Frigola, Patrick Aloy, Matthias Selbach, Douglas J. Winton, Eduard Batlle
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115003008

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http://www.sciencedirect.com/science/article/pii/S2213671115003008

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