Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, suggesting that the tumour suppressive function of...
| Główni autorzy: | , , , , , , , |
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| Format: | Artykuł |
| Język: | English |
| Wydane: |
Nature Portfolio
2018-09-01
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| Seria: | Nature Communications |
| Dostęp online: | https://doi.org/10.1038/s41467-018-06092-6 |