Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)

Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)

Introduction It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate if a 2-week interruption in low-dose weekly methotrexate treatment after SARS-CoV-2 vaccine boosters enh...

Full description

Bibliographic Details
Main Authors: Abhishek Abhishek, Daniel M Altmann, Lucy Eldridge, James Bluett, Anne Francis, Ines Rombach, Duncan Appelbe, Hywel C Williams, Vicki S Barber, Jonathan Alistair Cook, Ana M Valdes, Laura Coates, Lucy Cureton, Patrick Julier, Nicholas Peckham, Jonathan Nguyen-Van-Tam, RJ Boyton, Áine McKnight
Format: Article
Language:English
Published: BMJ Publishing Group 2022-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/12/5/e062599.full

Internet

https://bmjopen.bmj.com/content/12/5/e062599.full

Similar Items