P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis

P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis

IntroductionThis study provides evidence of how Th1 cell metabolism is modulated by the purinergic receptor P2X7 (P2RX7), a cation cannel activated by high extracellular concentrations of adenosine triphosphate (ATP).MethodsIn vivo analysis was performed in the Plasmodium chabaudi model of malaria i...

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Bibliographic Details
Main Authors: Érika Machado de Salles, Paulo Lisboa Raeder, Claudia Blanes Angeli, Verônica Feijoli Santiago, Cristiane Naffah de Souza, Theresa Ramalho, Niels Olsen Saraiva Câmara, Giuseppe Palmisano, José Maria Álvarez, Maria Regina D'Império Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
P2X7 signaling
Th1 cell differentiation
malaria
aerobic glycolysis
CD4 T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1140426/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1140426/full

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