Alternative pathway dysregulation and the conundrum of complement activation by IgG4 immune complexes in membranous nephropathy
Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes. In primary MN, auto-antibodies target proteins expressed on the podocyte surface, often phospholipase A2 recep...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00157/full |