LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration

LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration

Abstract LIMK1 and LIMK2 are key downstream targets to mediate the effects of the Rho family small GTPases and p21-activated kinases (PAK) in the regulation of the actin cytoskeleton. LIMKs are also critical for synaptic transmission, plasticity and memory formation. Changes in LIMK signaling are as...

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Bibliographic Details
Main Authors: Rui Mao, Rui Deng, Yan Wei, Lifang Han, Yanghong Meng, Wei Xie, Zhengping Jia
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Molecular Brain
Subjects:
Cortical development
LIMK1
LIMK2
Neuronal proliferation
Migration
Actin
Online Access:http://link.springer.com/article/10.1186/s13041-019-0487-7

Internet

http://link.springer.com/article/10.1186/s13041-019-0487-7

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