Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.

Coordination of gene expression with nutrient availability supports proliferation and homeostasis and is shaped by protein acetylation. Yet how physiological/pathological signals link acetylation to specific gene expression programs and whether such responses are cell-type-specific is unclear. AMP-a...

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Bibliographic Details
Main Authors: María Gutiérrez-Salmerón, José Manuel García-Martínez, Javier Martínez-Useros, María Jesús Fernández-Aceñero, Benoit Viollet, Severine Olivier, Jagat Chauhan, Silvia R Lucena, Antonio De la Vieja, Colin R Goding, Ana Chocarro-Calvo, Custodia García-Jiménez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000732

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https://doi.org/10.1371/journal.pbio.3000732

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