A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump

A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump

RND family efflux pumps are complex macromolecular machines involved in multidrug resistance by extruding antibiotics from the cell. While structural studies and molecular dynamics simulations have provided insights into the architecture and conformational states of the pumps, the path followed by c...

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Bibliographic Details
Main Authors: Anya Webber, Malitha Ratnaweera, Andrzej Harris, Ben F. Luisi, Véronique Yvette Ntsogo Enguéné
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antibiotics
Subjects:
allostery
antimicrobial resistance
conformational changes
efflux pump
energetic transition
gram-negative bacteria
Online Access:https://www.mdpi.com/2079-6382/11/1/52

Internet

https://www.mdpi.com/2079-6382/11/1/52

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