Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats

Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats

Alterations in dopamine neurotransmission are associated with obesity and food preferences. Otsuka Long-Evans Tokushima Fatty (OLETF) rats that lack functional cholecystokinin receptor type-1 (CCK-1R), due to a natural mutation, exhibit impaired satiation, are hyperphagic, and become obese. In addit...

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Bibliographic Details
Main Authors: Sevag Hamamah, Andras Hajnal, Mihai Covasa
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
dopamine
OLETF
obesity
sucrose
amphetamine
locomotor activity
Online Access:https://www.mdpi.com/1422-0067/24/11/9773

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https://www.mdpi.com/1422-0067/24/11/9773

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