Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Mycotoxins, fungal secondary metabolites, are ubiquitously present in food commodities. Acute exposure to high levels or chronic exposure to low levels has an impact on the human body. The phase I metabolism in the human liver, performed by cytochrome P450 (CYP450) enzymes, is accountable for more t...

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Bibliographic Details
Main Authors: Orphélie Lootens, Marthe De Boevre, Elke Gasthuys, Jan Van Bocxlaer, An Vermeulen, Sarah De Saeger
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Microbiology
Subjects:
mycotoxins
CYP450 enzymes
pharmacokinetic
in vitro
Michaelis–Menten constant
LC–MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.988083/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.988083/full

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