Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

eIF4A is a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5'-untranslated regions (UTRs) of mRNAs to promote their recruitment to the eukaryotic translation pre-initiation complex (PIC). We show that eIF4A's ATPase activity is markedly stimulated in the pres...

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Bibliographic Details
Main Authors: Paul Yourik, Colin Echeverría Aitken, Fujun Zhou, Neha Gupta, Alan G Hinnebusch, Jon R Lorsch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
ribosome
eIF4A
translation initiation
RNA helicase
eIF4F
mRNA recruitment
Online Access:https://elifesciences.org/articles/31476

Internet

https://elifesciences.org/articles/31476

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