OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

Abstract Androgen and androgen receptor (AR) targeted therapies are the main treatment for most prostate cancer (PC) patients. Although AR signaling inhibitors are effective, tumors can evade this treatment by transforming to an AR-negative PC via lineage plasticity. OCT1 is a transcription factor i...

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Bibliographic Details
Main Authors: Daisuke Obinata, Daigo Funakoshi, Kenichi Takayama, Makoto Hara, Birunthi Niranjan, Linda Teng, Mitchell G. Lawrence, Renea A. Taylor, Gail P. Risbridger, Yutaka Suzuki, Satoru Takahashi, Satoshi Inoue
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10099-x

Internet

https://doi.org/10.1038/s41598-022-10099-x

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