The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo

The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo

Abstract Background Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and compromises the viability of transplanted human bone marrow-derived mesenchymal stromal cells (BM-MSCs). Hence, BM-MSCs were genetically-engineered to express the anti-fibrotic and renoprotective hormone, human rel...

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Bibliographic Details
Main Authors: Yifang Li, Alex Hunter, Miqdad M. Wakeel, Guizhi Sun, Ricky W. K. Lau, Brad R. S. Broughton, Ivan E. Oyarce Pino, Zihao Deng, Tingfang Zhang, Padma Murthi, Mark P. Del Borgo, Robert E. Widdop, Jose M. Polo, Sharon D. Ricardo, Chrishan S. Samuel
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Stem Cell Research & Therapy
Subjects:
Chronic kidney disease
Fibrosis
BM-MSCs
Relaxin
Genetic engineering
Online Access:https://doi.org/10.1186/s13287-024-03992-x

Internet

https://doi.org/10.1186/s13287-024-03992-x

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