Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes. We have elucidated a critical and previously uncharacterized role for...

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Bibliographic Details
Main Authors: Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
malaria
isoprenoids
apicoplast
organelle biogenesis
polyprenol synthase
Online Access:https://elifesciences.org/articles/73208

Internet

https://elifesciences.org/articles/73208

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