Exercise sensitizes PD-1/PD-L1 immunotherapy as a hypoxia modulator in the tumor microenvironment of melanoma

Exercise sensitizes PD-1/PD-L1 immunotherapy as a hypoxia modulator in the tumor microenvironment of melanoma

IntroductionHypoxia is associated with unfavorable prognoses in melanoma patients, and the limited response rates of patients to PD-1/PD-L1 blockade could be attributed to the immunosuppressive tumor microenvironment induced by hypoxia. Exercise offers numerous benefits in the anti-tumor process and...

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Bibliographic Details
Main Authors: Huiyu Yan, Aimin Jiang, Yinong Huang, Jun Zhang, Wenguang Yang, Wei Zhang, Tianya Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
tumor microenvironment
exercise
hypoxia
PD-1/PD-L1 immunotherapy
immunotherapy sensitization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265914/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265914/full

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