Germline mutations in high penetrance genes are associated with worse clinical outcomes in patients with non–small cell lung cancerCentral MessagePerspective

Germline mutations in high penetrance genes are associated with worse clinical outcomes in patients with non–small cell lung cancerCentral MessagePerspective

Objective: To determine the frequency of pathogenic mutations in high-penetrance genes (HPGs) in patients with non–small cell lung cancer (NSCLC) and identify whether such mutations are associated with clinicopathologic outcomes. Methods: Patients with NSCLC who had consented to participate in a lin...

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Bibliographic Details
Main Authors: Seth B. Krantz, MD, Kanwal Zeeshan, MBBS, Kristine M. Kuchta, MS, Thomas A. Hensing, MD, Kathy A. Mangold, PhD, S. Lilly Zheng, MD, Jianfeng Xu, MD, DrPH
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:JTCVS Open
Subjects:
non–small cell lung cancer
high penetrance gene
DNA repair
polygenic risk score
germline mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273622003515

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http://www.sciencedirect.com/science/article/pii/S2666273622003515

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