Shikonin impairs mitochondrial activity to selectively target leukemia cells

Shikonin impairs mitochondrial activity to selectively target leukemia cells

Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy that results from the accumulation of undifferentiated myeloid cells in the peripheral blood and bone marrow. Limited therapeutics contribute to unfavorable patient outcomes, highlighting the need for novel therapeutics to improv...

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Bibliographic Details
Main Authors: Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Mark D. Minden, Julie A. Reisz, Angelo D'Alessandro, Jakub Rohlena, Paul A. Spagnuolo
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Phytomedicine Plus
Subjects:
Shikonin
Acute myeloid leukemia
Complex II
Succinate dehydrogenase
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031322000835

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http://www.sciencedirect.com/science/article/pii/S2667031322000835

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