Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte‐derived extracellular vesicles

Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte‐derived extracellular vesicles

Abstract Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are mechanosensitive cells that play fundamental roles in coordinating loading‐in...

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Bibliographic Details
Main Authors: Kian F. Eichholz, Ian Woods, Mathieu Riffault, Gillian P. Johnson, Michele Corrigan, Michelle C. Lowry, Nian Shen, Marie‐Noelle Labour, Kieran Wynne, Lorraine O'Driscoll, David A. Hoey
Format: Article
Language:English
Published: Oxford University Press 2020-11-01
Series:Stem Cells Translational Medicine
Subjects:
bone
extracellular vesicle
marrow stem cell
mechanobiology
proteomics
Online Access:https://doi.org/10.1002/sctm.19-0405

Internet

https://doi.org/10.1002/sctm.19-0405

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