Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells

Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is both a devastating and common disease. Every year in the United States, about 24,500 men and 10,000 women are diagnosed with HCC, and more than half of those diagnosed patients die from this disease. Thus far, conventional therapeutics have not been successful for p...

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Bibliographic Details
Main Authors: Francesca V. LoBianco, Kimberly J. Krager, Erica Johnson, Christopher O. Godwin, Antino R. Allen, Peter A. Crooks, Cesar M. Compadre, Michael J. Borrelli, Nukhet Aykin-Burns
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Toxicology
Subjects:
hepatocellular carcinoma (HCC)
parthenolide (PTL)
thiol oxidation
lipid peroxidation
ferroptosis
glutathione
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.936149/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2022.936149/full

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