Morphological and Proteomic Analyses Reveal that Unsaturated Guluronate Oligosaccharide Modulates Multiple Functional Pathways in Murine Macrophage RAW264.7 Cells

Morphological and Proteomic Analyses Reveal that Unsaturated Guluronate Oligosaccharide Modulates Multiple Functional Pathways in Murine Macrophage RAW264.7 Cells

Alginate is a natural polysaccharide extracted from various species of marine brown algae. Alginate-derived guluronate oligosaccharide (GOS) obtained by enzymatic depolymerization has various pharmacological functions. Previous studies have demonstrated that GOS can trigger the production of inducib...

Full description

Bibliographic Details
Main Authors:	Xu Xu, De-Cheng Bi, Chao Li, Wei-Shan Fang, Rui Zhou, Shui-Ming Li, Lian-Li Chi, Min Wan, Li-Ming Shen
Format:	Article
Language:	English
Published:	MDPI AG 2015-03-01
Series:	Marine Drugs
Subjects:	guluronate oligosaccharide macrophage activation nuclear factor-κB anti-inflammation antioxidant cell morphology
Online Access:	http://www.mdpi.com/1660-3397/13/4/1798

Similar Items

Unsaturated guluronate oligosaccharide used as a stabilizer of oil-in-water nanoemulsions loaded with bioactive nutrients
by: Decheng Bi, et al.
Published: (2022-12-01)

Alginate Oligosaccharides Prevent Dextran-Sulfate-Sodium-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Modulating Gut Microbiota
by: Axue Wu, et al.
Published: (2023-01-01)

Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages
by: Weishan Fang, et al.
Published: (2017-05-01)

Anti-inflammatory effect of chitosan oligosaccharides in RAW 264.7 cells
by: Yang Eun-Jin, et al.
Published: (2010-02-01)

Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against <i>Pseudomonas aeruginosa</i>
by: Manon F. Pritchard, et al.
Published: (2023-09-01)

Effect of Guluronic Acid (G2013), As a New Anti-inflammatory Drug on Gene Expression of Pro-inflammatory and Anti-inflammatory Cytokines and Their Transcription Factors in Rheumatoid Arthritis Patients
by: Tahereh Bakhtiari, et al.
Published: (2019-11-01)

Production of chitin oligosaccharides with different molecular weights and their antioxidant effect in RAW 264.7 cells
by: Dai-Nghiep Ngo, et al.
Published: (2009-04-01)

Immunomodulation of TLR2 and TLR4 by G2013 (alfa-L-Guluronic acid) in CVID Patients
by: Laleh Sharifi, et al.
Published: (2017-07-01)

کاربردهای G2013 (α-L-guluronic acid) به عنوان یک کاندیدای دارویی ضد التهابی در درمان بیماری‌ها
Published: (2021-04-01)

Enzymatic depolymerization of alginate by two novel thermostable alginate lyases from Rhodothermus marinus
by: Justyna M. Dobruchowska, et al.
Published: (2022-09-01)

Preparation of κ-carrageenan oligosaccharides by photocatalytic degradation: Structural characterization and antioxidant activity
by: Ziyu Li, et al.
Published: (2024-06-01)

Anti-Inflammatory Effects of Spiramycin in LPS-Activated RAW 264.7 Macrophages
by: Jin-Kyu Kang, et al.
Published: (2022-05-01)

Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages
by: Hao Tang, et al.
Published: (2015-08-01)

Anti-inflammatory effect of pomegranate flower in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages
by: Jianjun Xu, et al.
Published: (2017-01-01)

Pectin oligosaccharide from hawthorn fruit ameliorates hepatic inflammation via NF-κB inactivation in high-fat diet fed mice
by: Tuoping Li, et al.
Published: (2019-06-01)

The anti-inflammatory effect of Sonchus oleraceus aqueous extract on lipopolysaccharide stimulated RAW 264.7 cells and mice
by: Qi Li, et al.
Published: (2017-01-01)

Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
by: Minji Kim, et al.
Published: (2024-02-01)

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice
by: Xu Liu, et al.
Published: (2023-08-01)

Immune-enhancing effects of Hibiscus syriacus roots in RAW264.7 macrcophages
by: Hyun Ji Eo, et al.
Published: (2022-12-01)

Immunostimulatory effect of ethanol extract of Chondracanthus tenellus in RAW 264.7 macrophages in vitro
by: Cheol Park, et al.
Published: (2021-01-01)

Synergistic Inhibition of Pro-Inflammatory Pathways by Ginger and Turmeric Extracts in RAW 264.7 Cells
by: Xian Zhou, et al.
Published: (2022-05-01)

Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway
by: Li Yin, et al.
Published: (2023-04-01)

The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages
by: Zhao X, et al.
Published: (2020-05-01)

Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity
by: Wei Deng, et al.
Published: (2022-09-01)

Effect and molecular mechanism of isorhamnetin extracted from Ginkgo biloba on the differentiation of RAW264.7 cells into osteoclasts
by: LI Jing, et al.
Published: (2018-03-01)

Sophorolipid Suppresses LPS-Induced Inflammation in RAW264.7 Cells through the NF-κB Signaling Pathway
by: Ruiqi Xu, et al.
Published: (2022-08-01)

In vitro fermentation of κ-carrageenan oligosaccharides by human gut microbiota and its inflammatory effect on HT29 cells
by: Yujiao Sun, et al.
Published: (2019-08-01)

Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells
by: Su-Hyeon Cho, et al.
Published: (2022-01-01)

Anti-Inflammatory Effect of Simonsinol on Lipopolysaccharide Stimulated RAW264.7 Cells through Inactivation of NF-κB Signaling Pathway
by: Lian-Chun Li, et al.
Published: (2020-08-01)

<i>Momordica charantia</i> Suppresses Inflammation and Glycolysis in Lipopolysaccharide-Activated RAW264.7 Macrophages
by: Shi Yan Lee, et al.
Published: (2020-08-01)

Proteomic Analysis of Oligosaccharide Metabolism during the Growth and Development of Lycium barbarum Fruit
by: GAO Pengyan, LI Peipei, LIU Jun, MA Qin, LIU Dunhua
Published: (2023-06-01)

Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-κB and MAPK pathways
by: Junsheng Dong, et al.
Published: (2018-01-01)

Acylphloroglucinol Derivatives from Garcinia multiflora with Anti-Inflammatory Effect in LPS-Induced RAW264.7 Macrophages
by: Lin-Yang Cheng, et al.
Published: (2018-10-01)

Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages
by: Ming Fu, et al.
Published: (2023-01-01)

Anti-inflammatory Effects of Novel Thiazolidinone Derivatives as Bioactive Heterocycles on RAW264.7 Cells
by: Hossein Ghafoori, et al.
Published: (2017-02-01)

Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages
by: Jiayuan Wu, et al.
Published: (2023-05-01)

Enhanced Anti-Inflammatory Effects of Silibinin and Capsaicin Combination in Lipopolysaccharide-Induced RAW264.7 Cells by Inhibiting NF-κB and MAPK Activation
by: Yingying Zheng, et al.
Published: (2022-06-01)

Oligosaccharides in food and agriculture /
by: Eggleston, Gillian, 1963-, et al.
Published: (2003)

Anti-Inflammatory Effects of Fermented Lotus Root and Linoleic Acid in Lipopolysaccharide-Induced RAW 264.7 Cells
by: Sung Min Kim, et al.
Published: (2020-11-01)

Oligosaccharides from Sargassum thunbergii inhibit osteoclast differentiation via regulation of IRF-8 signaling
by: Weihua Jin, et al.
Published: (2023-02-01)