mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells

mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells

Epidermal Growth Factor receptor (EGFR) is a tyrosine kinase receptor widely expressed on the surface of numerous cell types, which activates several downstream signalling pathways involved in cell proliferation, migration and survival. EGFR alterations, such as overexpression or mutations, have bee...

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Bibliographic Details
Main Authors: Barbara Colella, Mayra Colardo, Gianna Iannone, Claudia Contadini, Cristina Saiz-Ladera, Claudia Fuoco, Daniela Barilà, Guillermo Velasco, Marco Segatto, Sabrina Di Bartolomeo
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
mTOR
EGFR
glioma
autophagy
Online Access:https://www.mdpi.com/2072-6694/12/8/2266

Internet

https://www.mdpi.com/2072-6694/12/8/2266

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