Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

Although preclinical and clinical studies have shown that exercise can inhibit bone metastasis progression, the mechanism remains poorly understood. Here, we found that non-small cell lung cancer (NSCLC) cells adjacent to bone tissue had a much lower proliferative capacity than the surrounding tumor...

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Bibliographic Details
Main Authors: Jing Xie, Yafei Xu, Xuhua Liu, Li Long, Ji Chen, Chunyan Huang, Yan Shao, Zhiqing Cai, Zhimin Zhang, Ruixin Zhou, Jiarong Leng, Xiaochun Bai, Qiancheng Song
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
exercise
osteocyte
bone metastasis
mechanical loading
tumor dormancy
Online Access:https://elifesciences.org/articles/89613

Internet

https://elifesciences.org/articles/89613

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