FAM193A is a positive regulator of p53 activity

FAM193A is a positive regulator of p53 activity

Summary: Inactivation of the p53 tumor suppressor, either by mutations or through hyperactivation of repressors such as MDM2 and MDM4, is a hallmark of cancer. Although many inhibitors of the p53-MDM2/4 interaction have been developed, such as Nutlin, their therapeutic value is limited by highly het...

Full description

Bibliographic Details
Main Authors: Maria M. Szwarc, Anna L. Guarnieri, Molishree Joshi, Huy N. Duc, Madison C. Laird, Ahwan Pandey, Santosh Khanal, Emily Dohm, Aimee K. Bui, Kelly D. Sullivan, Matthew D. Galbraith, Zdenek Andrysik, Joaquin M. Espinosa
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002413

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723002413

Similar Items