Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths worldwide. The development of drug resistance plays a k...

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Bibliographic Details
Main Authors: Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Translational Oncology
Subjects:
Retinoic acid
Resistance
Cisplatin
Aldehyde dehydrogenase
Cancer stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321000176

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http://www.sciencedirect.com/science/article/pii/S1936523321000176

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