A novel model of central precocious puberty disease: Paternal MKRN3 gene–modified rabbit

Abstract Background Makorin ring finger protein 3 gene (MKRN3) gene mutation is the most common genetic cause of central precocious puberty (CPP) in children. Due to the lack of ideal MKRN3‐modified animal model (MKRN3‐modified mice enter puberty only 4–5 days earlier than normal mice), the related...

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Bibliographic Details
Main Authors: Bangzhu Chen, Xing Ye, Lihao Chen, Tianping Liu, Guiling Li, Chula Sa, Juan Li, Ke Liu, Weiwang Gu, Gang Wang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Animal Models and Experimental Medicine
Subjects:
Online Access:https://doi.org/10.1002/ame2.12544