Control of gene expression through the nonsense-mediated RNA decay pathway

Control of gene expression through the nonsense-mediated RNA decay pathway

Abstract Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents translation of mutant mRNAs harboring premature termination codons (PTCs) by targeting...

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Bibliographic Details
Main Authors: Andrew Nickless, Julie M. Bailis, Zhongsheng You
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Cell & Bioscience
Subjects:
Nonsense-mediated decay
RNA surveillance
Gene expression
Human disease
Online Access:http://link.springer.com/article/10.1186/s13578-017-0153-7

Internet

http://link.springer.com/article/10.1186/s13578-017-0153-7

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