Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints
Rheumatoid arthritis (RA) is an immune-mediated disease of the joints that is characterized by chronic inflammation and synovial hyperplasia that eventually lead to cartilage and bone destruction.Synovial fibroblasts are mesenchymal cells recognized as a key cell population in RA due to their hyperp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00077/full |
| _version_ | 1818311806404263936 |
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| author | Noriko eKomatsu Noriko eKomatsu Hiroshi eTakayanagi Hiroshi eTakayanagi Hiroshi eTakayanagi |
| author_facet | Noriko eKomatsu Noriko eKomatsu Hiroshi eTakayanagi Hiroshi eTakayanagi Hiroshi eTakayanagi |
| author_sort | Noriko eKomatsu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is an immune-mediated disease of the joints that is characterized by chronic inflammation and synovial hyperplasia that eventually lead to cartilage and bone destruction.Synovial fibroblasts are mesenchymal cells recognized as a key cell population in RA due to their hyperproliferative and hypersentive properties in the inflammatory milieu and hyperproduction of both inflammatory cytokines and matrix degrading enzymes.On the immune cell side,a wealth of evidence has shown that CD4+T-cells, especially IL-17 producing helper T (Th17) cells, play a prominent role, particularly in the initiation of systemic immune response in RA.However,it is still unclear how the local chronic inflammation in the joint is elicited by a systemic immune response.Recent studies have shed light on the importance of the interaction between immune and mesenchymal cells in joints including synovial fibroblasts. In particular,mesenchymal cells contribute to the Th17-mediated chronic inflammation in RA by promoting the migration of Th17 cells to the inflamed site and then the homeostatic proliferation and concomitant increase in IL-17 production.In addition, recent progress in osteoimmunology has provided new insight into the pathogenesis of the bone destruction which takes place in RA.Th17-related cytokines have been shown to enhance osteoclastogenesis, mainly via synovial fibroblasts.Thus, mesenchymal cells are a determinant of the development of RA that links the systemic immune response and the local disorder in the joints.In addition, the interaction of immune and mesenchymal cells plays a key role in both the chronic inflammation and bone destruction seen in RA.Elucidation of the precise events involved in this interaction will lead to a better understanding of the mechanisms by which chronic inflammation and bone destruction in joint results from a systemic immune response,and also will help provide a molecular basis for novel therapeutic strategies to treat RA. |
| first_indexed | 2024-12-13T08:07:48Z |
| format | Article |
| id | doaj.art-d6e3ac4498fa48c39fc1a77302ac4d75 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T08:07:48Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d6e3ac4498fa48c39fc1a77302ac4d752022-12-21T23:54:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-04-01310.3389/fimmu.2012.0007722343Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in JointsNoriko eKomatsu0Noriko eKomatsu1Hiroshi eTakayanagi2Hiroshi eTakayanagi3Hiroshi eTakayanagi4Tokyo Medical and Dental UniversityGlobal Center of Excellence (GCOE) ProgramTokyo Medical and Dental UniversityGlobal Center of Excellence (GCOE) ProgramJapan Science and Technology Agency (JST), ERATORheumatoid arthritis (RA) is an immune-mediated disease of the joints that is characterized by chronic inflammation and synovial hyperplasia that eventually lead to cartilage and bone destruction.Synovial fibroblasts are mesenchymal cells recognized as a key cell population in RA due to their hyperproliferative and hypersentive properties in the inflammatory milieu and hyperproduction of both inflammatory cytokines and matrix degrading enzymes.On the immune cell side,a wealth of evidence has shown that CD4+T-cells, especially IL-17 producing helper T (Th17) cells, play a prominent role, particularly in the initiation of systemic immune response in RA.However,it is still unclear how the local chronic inflammation in the joint is elicited by a systemic immune response.Recent studies have shed light on the importance of the interaction between immune and mesenchymal cells in joints including synovial fibroblasts. In particular,mesenchymal cells contribute to the Th17-mediated chronic inflammation in RA by promoting the migration of Th17 cells to the inflamed site and then the homeostatic proliferation and concomitant increase in IL-17 production.In addition, recent progress in osteoimmunology has provided new insight into the pathogenesis of the bone destruction which takes place in RA.Th17-related cytokines have been shown to enhance osteoclastogenesis, mainly via synovial fibroblasts.Thus, mesenchymal cells are a determinant of the development of RA that links the systemic immune response and the local disorder in the joints.In addition, the interaction of immune and mesenchymal cells plays a key role in both the chronic inflammation and bone destruction seen in RA.Elucidation of the precise events involved in this interaction will lead to a better understanding of the mechanisms by which chronic inflammation and bone destruction in joint results from a systemic immune response,and also will help provide a molecular basis for novel therapeutic strategies to treat RA.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00077/fullInflammationRheumatoid arthritissynovial fibroblastosteoclastTh17 cellbone destruction |
| spellingShingle | Noriko eKomatsu Noriko eKomatsu Hiroshi eTakayanagi Hiroshi eTakayanagi Hiroshi eTakayanagi Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints Frontiers in Immunology Inflammation Rheumatoid arthritis synovial fibroblast osteoclast Th17 cell bone destruction |
| title | Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints |
| title_full | Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints |
| title_fullStr | Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints |
| title_full_unstemmed | Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints |
| title_short | Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal cells in Joints |
| title_sort | inflammation and bone destruction in arthritis synergistic activity of immune and mesenchymal cells in joints |
| topic | Inflammation Rheumatoid arthritis synovial fibroblast osteoclast Th17 cell bone destruction |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00077/full |
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