Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation

Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation

Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability following oral administration. These unfavorable p...

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Bibliographic Details
Main Authors: Aslıhan Arslan, Barbaros Yet, Emirhan Nemutlu, Yağmur Akdağ Çaylı, Hakan Eroğlu, Levent Öner
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
celecoxib
dry co-milling
response surface methodology
central composite design
black-box
Bayesian optimization
Online Access:https://www.mdpi.com/1999-4923/15/2/363

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https://www.mdpi.com/1999-4923/15/2/363

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