Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro

Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro

Oxidation of LDL generates biologically active platelet-activating factor (PAF)-like phospholipid derivatives, which have potent proinflammatory activity. These products are inactivated by lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme capable of hydrolyzing PAF-like phospholipids. In...

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Bibliographic Details
Main Authors: Päivi Turunen, Johanna Jalkanen, Tommi Heikura, Hanna Puhakka, Jouni Karppi, Kristiina Nyyssönen, Seppo Ylä-Herttuala
Format: Article
Language:English
Published: Elsevier 2004-09-01
Series:Journal of Lipid Research
Subjects:
lipoprotein-associated phospholipase A2
low density lipoprotein
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312797

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http://www.sciencedirect.com/science/article/pii/S0022227520312797

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