Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness.

Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness.

Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in spiral ligament fibrocytes, however the molecular...

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Váldodahkkit: Yoshinobu Kidokoro, Keiko Karasawa, Osamu Minowa, Yoshinobu Sugitani, Tetsuo Noda, Katsuhisa Ikeda, Kazusaku Kamiya
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Public Library of Science (PLoS) 2014-01-01
Ráidu:PLoS ONE
Liŋkkat:http://europepmc.org/articles/PMC4178122?pdf=render

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http://europepmc.org/articles/PMC4178122?pdf=render

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