CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1.
Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total IgG and the IgG subclasses and the monocyte IgG receptor, known as FcγRIIIa...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-08-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4125298?pdf=render |
| _version_ | 1818368679042088960 |
|---|---|
| author | Laura J Appleby Norman Nausch Louise Erskine Claire D Bourke Nadine Rujeni Nicholas Midzi Takafira Mduluza Francisca Mutapi |
| author_facet | Laura J Appleby Norman Nausch Louise Erskine Claire D Bourke Nadine Rujeni Nicholas Midzi Takafira Mduluza Francisca Mutapi |
| author_sort | Laura J Appleby |
| collection | DOAJ |
| description | Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total IgG and the IgG subclasses and the monocyte IgG receptor, known as FcγRIIIa or CD16, in schistosome exposed people. Systemic levels of schistosome-specific anti-adult worm total IgG and IgG subclass titres were measured by ELISA in 100 individuals from an S. haematobium endemic area in Zimbabwe and, using parametric statistical methods and regression analysis, related to the levels of CD16 expression on individuals' circulating monocytes, determined via flow cytometry. Monocyte CD16 expression rose with parasite-specific total IgG and IgG1 in healthy participants, but not in schistosome infected patients. Similar to parasite-specific IgG and IgG1, CD16 expression in healthy individuals is associated with protection against schistosome infection. This relationship indicates a mechanistic link between the innate and adaptive immune responses to helminth infection in protection against infection. Further understanding the elements of a protective immune response in schistosomiasis may aid in efforts to develop a protective vaccine against this disease. |
| first_indexed | 2024-12-13T23:11:46Z |
| format | Article |
| id | doaj.art-d6eb81449bab42709ce7bcb9b0b832ac |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-13T23:11:46Z |
| publishDate | 2014-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-d6eb81449bab42709ce7bcb9b0b832ac2022-12-21T23:28:06ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-08-0188e304910.1371/journal.pntd.0003049CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1.Laura J ApplebyNorman NauschLouise ErskineClaire D BourkeNadine RujeniNicholas MidziTakafira MduluzaFrancisca MutapiHuman IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total IgG and the IgG subclasses and the monocyte IgG receptor, known as FcγRIIIa or CD16, in schistosome exposed people. Systemic levels of schistosome-specific anti-adult worm total IgG and IgG subclass titres were measured by ELISA in 100 individuals from an S. haematobium endemic area in Zimbabwe and, using parametric statistical methods and regression analysis, related to the levels of CD16 expression on individuals' circulating monocytes, determined via flow cytometry. Monocyte CD16 expression rose with parasite-specific total IgG and IgG1 in healthy participants, but not in schistosome infected patients. Similar to parasite-specific IgG and IgG1, CD16 expression in healthy individuals is associated with protection against schistosome infection. This relationship indicates a mechanistic link between the innate and adaptive immune responses to helminth infection in protection against infection. Further understanding the elements of a protective immune response in schistosomiasis may aid in efforts to develop a protective vaccine against this disease.http://europepmc.org/articles/PMC4125298?pdf=render |
| spellingShingle | Laura J Appleby Norman Nausch Louise Erskine Claire D Bourke Nadine Rujeni Nicholas Midzi Takafira Mduluza Francisca Mutapi CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. PLoS Neglected Tropical Diseases |
| title | CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. |
| title_full | CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. |
| title_fullStr | CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. |
| title_full_unstemmed | CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. |
| title_short | CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. |
| title_sort | cd16 expression on monocytes in healthy individuals but not schistosome infected patients is positively associated with levels of parasite specific igg and igg1 |
| url | http://europepmc.org/articles/PMC4125298?pdf=render |
| work_keys_str_mv | AT laurajappleby cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT normannausch cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT louiseerskine cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT clairedbourke cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT nadinerujeni cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT nicholasmidzi cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT takafiramduluza cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 AT franciscamutapi cd16expressiononmonocytesinhealthyindividualsbutnotschistosomeinfectedpatientsispositivelyassociatedwithlevelsofparasitespecificiggandigg1 |