Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction

Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction

Sympathetic denervation of the heart following ischemia/reperfusion induced myocardial infarction (MI) is sustained by chondroitin sulfate proteoglycans (CSPGs) in the cardiac scar. Denervation predicts risk of sudden cardiac death in humans. Blocking CSPG signaling restores sympathetic axon outgrow...

Full description

Bibliographic Details
Main Authors: Matthew R Blake, Diana C Parrish, Melanie A Staffenson, Shanice Sueda, William R Woodward, Beth A Habecker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
chondroitin sulfate proteoglycan
sympathetic nerves
nerve regeneration
myocardial infarction
Online Access:https://elifesciences.org/articles/78387

Internet

https://elifesciences.org/articles/78387

Similar Items